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Mitochondrial Research

The SS-31 Masterclass | Complete Researcher’s Guide (2026)

SS-31 · 50mg

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About this compound

SS-31 (Elamipretide, also known as MTP-131 or Bendavia) is a synthetic mitochondria-targeted tetrapeptide (D-Arg-2',6'-dimethylTyr-Lys-Phe-NH₂) that selectively binds cardiolipin on the inner mitochondrial membrane. It is widely studied in preclinical models for stabilizing cristae architecture, improving electron transport chain efficiency, and reducing mitochondrial reactive oxygen species.

  • Investigated for cardiolipin binding and inner-membrane cristae stabilization.
  • Studied in models of ischemia-reperfusion injury and heart failure.
  • Evaluated in primary mitochondrial myopathy and age-related muscle decline.

Citations

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